A diastereomerically enriched, dimeric organolithium compound and the stereochemical course of its transformations.
نویسندگان
چکیده
A dimeric α-silylated ethyllithium compound is presented featuring stereogenic metalated carbon centres with defined configurations. It can be generated by diastereoselective deprotonation of the corresponding ethylsilane. Reaction with Me(3)SnCl proceeds under inversion and the transfer of the stereoinformation is possible with dr's of up to 97:3.
منابع مشابه
Reduction of hydroxy-functionalised carbaboranyl carboxylic acids and ketones by organolithium reagents.
While the reaction of carbaboranyl carboxylic acids and ketones with organolithium reagents generally leads to cleavage of the exo-polyhedral C-C bond, introduction of a hydroxyl group at the second carbon atom of the cluster enables the reduction of the carbonyl compounds to tertiary alcohols. The proposed mechanism involving the formation of dimeric contact ion pairs was supported by X-ray cr...
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عنوان ژورنال:
- Chemical communications
دوره 48 19 شماره
صفحات -
تاریخ انتشار 2012